Posts Tagged ‘bipolar disorder’

Research Focus: Bipolar Disorder in a Dish

A research study has used a new cellular model to see “inside” the brains of people with bipolar disorder. We can’t always see what we want to see inside the bodies of living people, despite all the technology we have for looking—from X-ray to MRI to endoscopy.  In particular, our methods for looking at living people’s brains are pretty limited. One of the common ways around this, especially when we want to learn about a disorder affecting humans is to study a model of the illness. Animal models are the most common—say, a mouse or rat that has been subjected to stress or trauma and shows signs of anxiety or depression. Such models are somewhat limited since we can’t ask the animal how it is feeling, and because rodent behavior is much less complicated than human behavior. A cellular model is another option—a cell that can be grown in the […]

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Depression Breakthrough? The Many Faces of “Special K”

Recently, a 45-year-old anesthetic drug has been getting attention as a remarkably effective antidepressant. Ketamine is used for anesthesia in children as well as adults and animals, and sometimes for relief of chronic pain. It’s considered very safe. But it’s also known as Special K among people who use it as a hallucinogenic club drug. What makes ketamine special in mental illness is that it is the first truly new potential drug treatment in more than 50 years. Exploratory studies going back 13 years have suggested that ketamine has some unique effects in people with depression, both unipolar major depressive disorder and bipolar depression. So, what’s the big deal? First, ketamine acts fast. Unlike most current antidepressants on the market, which can take 6-8 weeks to work, ketamine shows antidepressant effects within 24 hours, sometimes in just a couple of hours. Second, ketamine works in people with treatment-resistant depression. A […]

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